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Dr. Varada Arora is currently practicing as a Gynaecologist and Infertility Specialist in Valencia IVF Center. Valencia IVF Center is one of the premier Fertility Clinics located in Lucknow. 

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Role of Genetics in Male and Female Infertility

Role of Genetics in Male and Female Infertility

Genes are transferred from one generation to another generation and genetics plays an important role in both males and females. Your fertility can be influenced by lifestyle choices, genetic components, environmental factors, and biological factors. Conceiving a baby due to genetic disorders is most common nowadays. Let’s understand what is the role of genetics in male and female fertility.  

What Are The Reasons Behind Genetic Disorders in Male and Female Infertility? 

Infertility may be related to genetic factors such as deletion of a piece of a chromosome, inversion in the chromosome that could be upside down, mutation in the gene’s DNA sequence, Aneuploidy, or translocation in the chromosome. 

Genetic Disorders and Male Infertility

Genetic disorders are a cause behind male infertility such as cystic fibrosis, gene mutation, chromosomal abnormalities, Noonan syndrome, and chromosomal translocation. Other than these disorders, varicocele is also linked with genetic factors that negatively impact sperm quality. An infertile man can consult a Male infertility doctor in Lucknow to get the right treatment and diagnosis. 

Relation of Sperms and Genetic Factors 

Genetics may be the reason behind spermatogenesis (disrupts the ability to produce healthy sperm cells), azoospermia (blocks the ability to produce sperm cells), and oligospermia (low sperm quality). Due to genetic disorders, men might face Kleinfelter syndrome which means an additional X chromosome in males causes Kleinfelter syndrome (47, XXY).  Microdeletion on the Y chromosome negatively impacts sperm production. 

Genetic Disorders Behind Female Infertility 

Chromosomal abnormalities can cause female infertility that affects in several ways while conceiving a baby. Let’s understand what are the genetic disorders behind female infertility. 

1. Kallmann syndrome causes female infertility to occur due to the inability to produce hypothalamic hormone.

2. Mutations in the cystic fibrosis gene that result in ovulation issues.

3. Primary ciliary dyskinesia causes infertility in women which results in problems in the fallopian tubes.

Women with a family history of problems conceiving due to endometriosis that genetic issues can cause might face problems while conceiving a baby.

Also Read – How to Naturally Improve Egg Quality for IVF Success?

Do Genetic Disorders Result in Recurrent Pregnancy Loss?

Chromosomal abnormalities in either partner can lead to recurrent miscarriages. With the help of preimplantation genetic testing, analysis of embryos for Sickle cell anemia, Cystic fibrosis, Huntington’s disease, risk of breast or ovarian cancer in a female child, and Fragile-X syndrome can be identified. This technology improves the selection of better embryos and improves the chances of successful implantation and pregnancy.

It is necessary to understand those genetic factors that influence fertility and with the help of a personalized treatment plan, an infertile couple can improve its journey towards parenthood. But, before undergoing any treatment it is necessary to understand each step of that treatment. Fertility treatment should be based on your genetic profile and what challenges you are facing while conceiving a baby. Infertility Female Center in Lucknow provides the right treatment plan and guidance during this tough phase. 

What Are The Benefits of Preimplantation Genetic Testing?

Pre-implantation genetic testing offers many benefits such as reducing the risk of inherited genetic disorders in the next generation. By selecting embryos with the right chromosomal formation, there are high chances of successful IVF or other fertility treatment. This process reduces the risk of miscarriage and failed pregnancies that occur due to genetic disorders. Pre-implantation genetics can save many couples from the emotional stress that may occur due to their childbirth (who are facing a genetic disorder).


Genetics plays an important role in males and females. In males, genetics are responsible for sperm production and other reproductive functions whereas genetics in females are responsible for the function of ovaries and overall reproductive functions. Changes in genes are related to egg quality, ovulation, menstrual cycle, changes in sperm structure, sperm abnormalities, and sperm quality that impact the fertility of females and males. 

Understanding the genetic basis of fertility can help in the diagnosis and treatment of specific infertility issues. Identifying genetic disorders helps many couples to get the right treatments. Genetics plays an important role in the shaping processes of the new individual. With the help of preimplantation genetic testing, your embryos can be analyzed for many genetic disorders like Sickle cell anemia, Cystic fibrosis, and other genetic disorders can be identified. Pre-implantation genetic testing helps in choosing the right embryo before implantation and reduces the risk of miscarriage.

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Dr. Varada Arora is currently practicing as a Gynaecologist and Infertility Specialist in Valencia IVF Center. Valencia IVF Center is one of the premier Fertility Clinics located in Lucknow. It is just 12 kilometres away from Central railway station and bus terminal.